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Effect of Age on Optimal Clinical Dose of Dexmedetomidine Sedation
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ÃÖÀ±Áö ( Choi Yoon-Ji ) - ¼¿ï´ëÇб³ Ä¡°úº´¿ø Ä¡°ú¸¶Ãë°ú
¹éÀç¿ø ( Baik Jae-Won ) - ¼¿ï¾Æ»êº´¿ø ¸¶ÃëÅëÁõÀÇÇаú
³ë¿µÁø ( Ro Young-JIn ) - ¼¿ï¾Æ»êº´¿ø ¸¶ÃëÅëÁõÀÇÇаú
KMID : 0980220140140030151
Abstract
Background: Dexmedetomidine is known to be administered for sedation safely even in a very elderly patient. The purpose
of this study was to determine the effect of age on clinically optimal dose of dexmedetomidine for sedation.
Methods: We enrolled 50 patients ASA class I and II, scheduled for lower extremity surgery that need. They were classified into a young group (n = 26), aged below 75 and an old group (n = 24), aged above 75. Dexmedetomidine was continuously infused 0.5 ¥ìg/kg within 10 min, followed by maintenance at a dose of 0.5 ¥ìg/kg/min, initially. The next dose was selected using the Dixon¡¯s up-and-down method.
Results: The cED50 of dexmedetomidine required to maintain optimal sedation level in young and old group were 0.50 and
0.48 ¥ìg/kg, respectively. With isotonic regression, cED95 of dexmedetomidine was 0.71 ¥ìg/kg (95% confidence intervals 0.57-1.06¥ìg/kg) and 0.58 ¥ìg/kg (95% confidence intervals 0.51-0.67 ¥ìg/kg). There were no significant differences in cED50 (P = 0.21), recovery variables, or incidence of side effects between the two groups.
Conclusions: Clinically optimal dose of dexmedetomidine was not affected to the age during sedation.
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Dexmedetomidine; Elderly; Sedation
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